Your body already knows how to heal, it just needs the right signals to remember?

Why a Woman 45+ Should Even Consider Peptides

1. Recovery is no longer automatic.
Your body’s internal signaling for angiogenesis (new blood vessel formation), fibroblast migration, collagen remodeling, and mitochondrial resilience weakens with age. Peptides act like amplifiers, cleaning and sharpening those repair cues so tissue healing actually happens.

2. Life load is heavier than ever.
Work demands, caregiving responsibilities, disrupted sleep, and fluctuating hormones all drive oxidative stress and chronic inflammation, even with a clean diet and regular workouts. Peptides help quiet the inflammatory noise and give recovery a fighting chance.

3. Targeted signals outperform shotgun supplements.
Unlike broad-spectrum anti-inflammatories or random “joint support” blends, each peptide is designed to support a specific phase of healing:
→ Calm inflammation
→ Recruit repair cells
→ Rebuild blood flow
→ Remodel collagen and tissue structure

Safety is Important: What Responsible Use Looks Like?

In my practice, protocols are conservative, short 4–8 week cycles, guided by labs and symptom feedback.

We avoid use in:

• Active malignancy or proliferative conditions

• Pregnancy and breastfeeding

• Around surgical procedures if your surgeon requests a pause

• Those with copper sensitivity (when using GHK-Cu systemically)

Sterility, sourcing, and proper storage are non-negotiable. If you’re not working with a clinician who understands this landscape, you’re taking unnecessary risks.

Your Healing Core Players

BPC-157: Supports microcirculation and gut lining. Calms irritated tendons and ligaments, promoting stable recovery.

TB-500 (Thymosin β4 fragment): Mobilizes repair cells to the injury site. Best during active tissue remodeling phases.

KPV: A small anti-inflammatory fragment that quiets cytokine overactivity, ideal for “hot” tendons, angry joints, reactive skin, or gut flares.

GHK-Cu (Copper Peptide): Reboots gene expression for collagen and elastin; enhances both skin and internal tissue repair. Excellent topically.

Epithalon: Regulates circadian rhythm and cellular longevity, often noticed through better sleep and calmer nervous system function.

MOTS-c: A mitochondrial peptide that improves stress tolerance and metabolic flexibility, key for women dealing with fatigue or insulin resistance.

NAD+: Foundational for cellular energy and redox balance. Dosing should be symptom-guided and lab-informed.

Let Bloodwork Guide the Choice

You don’t need perfect labs to start, but labs make your plan smarter and safer. Here’s how I use markers to inform peptide decisions:

Inflammation Check

• hs-CRP >1.0 mg/L → systemic inflammation likely

• Ferritin <40 ng/mL or >150 ng/mL → inflammatory or iron-related healing delays

• Omega-3 Index <6% → poor anti-inflammatory tone

If inflammation is high → KLOW blend (BPC-157 + TB-500 + GHK-Cu + KPV).

Slow Tissue Remodeling

• Vitamin D <40 ng/mL → collagen and tissue healing lag

• History of slow tendon/skin repair → use Glow blend (BPC-157 + TB-500 + GHK-Cu).

Gut Inflammation Present

• Elevated hs-CRP with bloating, loose stools, reflux

• Abnormal stool calprotectin or zonulin
  → Stay with KLOW (KPV is critical here).

Energy or Metabolic Slowdown

• Fasting insulin >8 μIU/mL, A1c ≥5.6%, HOMA-IR >1.8
  → Add MOTS-c or NAD+ cycles for better metabolic recovery.

Baseline Panels I Recommend:
CBC, CMP, lipid panel, A1c, fasting glucose & insulin, ferritin + iron panel, vitamin D, hs-CRP, thyroid (TSH + free T4/T3). Add Omega-3 Index and stool tests when indicated.

Singles vs Blends: How to Choose

Single Peptide Use

• Minor tendon flare, good energy → BPC-157 alone

• Skin/scar recovery → GHK-Cu topical ± Epithalon

• Fatigue/metabolic drag → MOTS-c cycles

Glow Blend (BPC-157 + TB-500 + GHK-Cu)

• Tissue remodeling with moderate inflammation

• Post-microneedling, laser, or surgical scar healing

KLOW Blend (Glow + KPV)

• Inflamed, painful tendons or joints

• Post-op or gut-linked soft tissue issues

• Elevated hs-CRP or chronic inflammation
  
  

Dosing: Safe, Effective Starting Framework

Cycle: 4–8 weeks, then reassess. Subcutaneous injections. Refrigerate after reconstitution.

KLOW Blend:

• Start: 0.15 mL daily (~BPC-157 500 mcg, TB-500 500 mcg, KPV 500 mcg, GHK-Cu 2.5 mg)

• Acute pain: up to 0.20 mL for 1–2 weeks

• Maintenance: 0.10 mL daily for 2–4 weeks

Glow Blend:

• Start: 0.15 mL daily (same peptide ratios minus KPV)

• Short high-intensity phase: 0.20 mL temporarily

Singles:

• BPC-157: 250–500 mcg daily

• TB-500: 2–5 mg/week, divided

• KPV: 250–500 mcg once or twice daily

• GHK-Cu: topical 1–2×/day on clean skin

• Epithalon: cyclical, low nightly dosing

• MOTS-c: 1–3×/week during training or metabolic stress

• NAD+: low-dose oral/IV during high-load recovery

Real-World Scenarios

Perimenopause + Achilles Flare + hs-CRP 2.1 mg/L:
Use KLOW 0.15 mL daily (up to 0.20 mL for first 1–2 weeks).
Correct vitamin D ≥40 ng/mL, aim Omega-3 Index ≥8%, maintain ~100 g/day protein, and reassess at week 6–8.

Post-Microneedling + No Systemic Inflammation:
Glow 0.15 mL daily × 4 weeks + GHK-Cu topical for scar remodeling.

Fatigue + Insulin Resistance (A1c 5.8%, fasting insulin 12 μIU/mL):
MOTS-c 1–2×/week × 6 weeks.
Add Glow if tendon recovery is slow; KLOW if joint inflammation is active.

Key Safety Reminders

• Avoid it if you have active cancer or proliferative retinopathy.

• Pause around surgeries if your surgeon requests.

• Avoid systemic GHK-Cu with copper sensitivity.

• Recheck labs if you started with high hs-CRP, low vitamin D, or metabolic issues.

This content is educational, not medical advice. Always coordinate with a qualified clinician before starting any peptide therapy.